The potential of nitric oxide therapeutics in stroke.

摘要: The therapeutic modulation of the nitric oxide (NO) system has generated considerable interest as a new way for managing many disease processes. In stroke, useful strategy is to increase NO availability and thereby exploit its beneficial antiplatelet, antiatherosclerotic, haemodynamic neuroprotective properties. Pharmacologically, this can be achieved by providing substrate, using donors or upregulating synthase. Alternatively, one reduce inhibiting synthase limiting pro-inflammatory neurotoxic This article reviews developments in NO-related therapeutics treatment with particular emphasis on compounds that are clinical research development pipeline. Although routine use prevention stroke cannot currently recommended, we evidently at an exciting stage their pharmacological development. Definitive randomised controlled trials patients required matter urgency.