Green One Pot Solvent-Free Synthesis of Pyrano[2,3-c]-Pyrazoles and Pyrazolo[1,5-a]Pyrimidines
作者： Hamad M. Al-Matar , Khaled D. Khalil , Aisha Y. Adam , Mohamed H. Elnagdi
DOI: 10.3390/MOLECULES15096619
关键词:
摘要: Pyrano[2,3-c]pyrazoles are obtained via mixing ethyl acetoacetate, hydrazine hydrate, aldehydes or ketones and malononitrile in the absence of solvent. These same products were also by reacting arylidenemalononitriles 3 with 3-methyl-2-pyrazolin-5-ones. NOE difference experiments confirmed that these exist solely 2H form. Similar treatments 3-amino-2-pyrazolin-5-one arylidene-malononitrile afforded adduct 6. Similarly cyanoacetate, aldehydes, gave product A novel synthesis 4-oxo-4H-pyrano[2,3-c]pyrazole (8) could be achieved 3-methyl-2-pyrazolin-5-one a mixture cyanoacetic acid acetic anhydride. treatment 3-aminopyrazole 11 benzylidene-malononitrile produced pyrazolo[2,3-a]pyrimidines 12a,b.
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