作者: R Bernhardt , G Huber , A Matus
DOI: 10.1523/JNEUROSCI.05-04-00977.1985
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摘要: The developmental distribution patterns of microtubule-associated proteins (MAPs) 1, 2, and 3 were studied using three monoclonal antibodies. Immunochemical staining at the light electron microscopic levels demonstrated specific localization each MAP in different cellular subcellular compartments. MAP2, which is specifically associated with dendritic microtubules adult brain, strictly growing dendrites from onset their formation. MAP3, a recently described Mr = 180,000, brain neurofilament-rich axons glial processes, beginning outgrowth. Although MAP3 not detectable granule cells parallel fiber mature cerebellum, it does appear transitorily these during development. During neuronal differentiation, MAP1 found first only later where highest concentrations are eventually to be found. These results indicate that combined appearance MAP2 (dendrites) or (axons) correlates morphologically distinct provide further evidence MAPs molecular determinants axonal