Differences in the developmental patterns of three microtubule-associated proteins in the rat cerebellum.

作者: R Bernhardt , G Huber , A Matus

DOI: 10.1523/JNEUROSCI.05-04-00977.1985

关键词:

摘要: The developmental distribution patterns of microtubule-associated proteins (MAPs) 1, 2, and 3 were studied using three monoclonal antibodies. Immunochemical staining at the light electron microscopic levels demonstrated specific localization each MAP in different cellular subcellular compartments. MAP2, which is specifically associated with dendritic microtubules adult brain, strictly growing dendrites from onset their formation. MAP3, a recently described Mr = 180,000, brain neurofilament-rich axons glial processes, beginning outgrowth. Although MAP3 not detectable granule cells parallel fiber mature cerebellum, it does appear transitorily these during development. During neuronal differentiation, MAP1 found first only later where highest concentrations are eventually to be found. These results indicate that combined appearance MAP2 (dendrites) or (axons) correlates morphologically distinct provide further evidence MAPs molecular determinants axonal

参考文章(20)
Wilhelm HERZOG, Klaus WEBER, Fractionation of Brain Microtubule‐Associated Proteins FEBS Journal. ,vol. 92, pp. 1- 8 ,(1978) , 10.1111/J.1432-1033.1978.TB12716.X
Constantino Sotelo, Purkinje Cell Ontogeny: Formation and Maintenance of Spines Progress in Brain Research. ,vol. 48, pp. 149- 170 ,(1978) , 10.1016/S0079-6123(08)61021-3
Don W. Cleveland, Shu-Ying Hwo, Marc W. Kirschner, Purification of tau, a microtubule-associated protein that induces assembly of microtubules from purified tubulin. Journal of Molecular Biology. ,vol. 116, pp. 207- 225 ,(1977) , 10.1016/0022-2836(77)90213-3
Jacques FRANCON, Ana Maria LENNON, Arlette FELLOUS, Alain MARECK, Michel PIERRE, Jacques NUNEZ, Heterogeneity of Microtubule-Associated Proteins and Brain Development FEBS Journal. ,vol. 129, pp. 465- 471 ,(1982) , 10.1111/J.1432-1033.1982.TB07072.X
P. De Camilli, P.E. Miller, F. Navone, W.E. Theurkauf, R.B. Vallee, Distribution of microtubule-associated protein 2 in the nervous system of the rat studied by immunofluorescence Neuroscience. ,vol. 11, pp. 819- 846 ,(1984) , 10.1016/0306-4522(84)90194-5
A. Matus, R. Bernhardt, T. Hugh-Jones, High molecular weight microtubule-associated proteins are preferentially associated with dendritic microtubules in brain. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 78, pp. 3010- 3014 ,(1981) , 10.1073/PNAS.78.5.3010