Molecular Epidemiology of Japanese Encephalitis Virus

摘要: Japanese encephalitis (JE) virus causes an encephalitic disease in humans that is characterized by a wide range of symptoms from nonspecific febrile illness to convulsions, seizure, and death (Solomon et al. 2000). Approximately 30% patients presenting at hospital with JE will succumb the about 50% those who survive have severe neurological sequelae The carried mosquitoes, primarily Culex species, endemic tropical temperate regions Asia Australasia. generally considered circulate cycle southern whereas tends more epidemic epidemiological pattern northern outbreaks occurring during summer months (Vaughn Hoke 1992). infects number animal hosts, most importantly pigs, which act as amplifying hosts are found high numbers throughout rural Asia. first isolate virus, prototype strain, was isolated 1935 Tokyo human brain designated Nakayama strain. Since time, large isolates been identified geographical locales Asia, Indonesia, recently, Australia. Many these viruses analyzed serologically and/or genetically examine distribution strains over both temporal boundaries. To date, complete genome 20 sequenced including Australia (Williams