Lymphocyte—Epithelial Cross-Talk in the Intestine: Do Nonclassical Class I Molecules Have a Big Part in the Dialogue?

摘要: Publisher Summary This chapter focuses on the behavior and properties of nonclassical class I molecules expressed by mouse intestinal epithelial cells, possible role these may have in development function intraepithelial lymphocytes (IEL). IEL a phenotype that is distinct from other T-cell populations, be product separate, thymus-independent lineage. If such lineage exists, it would likely epithelium plays major its development. It also possible, however, some are derived thymus-derived T cells. evidenced ability conventional CD4+ cells to home gut scid mice, acquire characteristics normally reside intestine. shows nonpolymorphic intestine unique properties, most notably, their lack requirement for TAP order cell surface. provide insight into specialized TL antigen mCDl mucosal immune system. further demonstrates can as an antigen-presenting molecule, presents peptide antigens those presented classical molecules.