Reassortment and Insertion-Deletion Are Strategies for the Evolution of Influenza B Viruses in Nature

摘要: The evolution of influenza B viruses is poorly understood. Reassortment in nature as a means genetic variation has not been considered to be major contributor their evolution. However, the current practice assigning evolutionary relationships by antigenic analysis hemagglutinin would fail detect reassortants. In this study, isolated within past 10 years from sites United States and China were studied nucleotide sequencing neuraminidase genes construction phylogenetic trees assess relationships. A group represented B/Houston/1/92 possess derived B/Yamagata/16/88-like strain B/Victoria/2/87-like strain. second reassortment event between virus closely related B/Beijing/184/93 single virus, B/Memphis/3/93. reassortant most that currently circulating Nanchang, China. pattern insertions deletions different strains observed. plays role may necessitate change methods used identify new viruses.