Antineoplastic activity of new lanthanide (cerium, lanthanum and neodymium) complex compounds.

摘要: Cerium (III), lanthanum (III) and neodymium complexes with 3,3'-benzylidenebis[4-hydroxycoumarin] were synthesized in view of their application as cytotoxic agents. The characterized by different physicochemical methods: elemental analysis, mass spectrometry, 1H NMR, 13C NMR IR spectroscopy. spectra the interpreted on basis comparison spectrum free ligand. vibrational analysis showed that ligand coordinated to metal ion through both deprotonated hydroxyl groups; however, participation carbonyl groups coordination was also suggested. evaluation activity novel lanthanide HL-60 myeloid cells revealed they are potent cerium complex found exhibit superior compounds, latter being least active. Our data give us reason conclude newly should be submitted further more detailed pharmacological toxicological evaluation.