“Nephritic flares” are predictors of bad long-term renal outcome in lupus nephritis

摘要: We retrospectively analyzed the courses of 70 patients with lupus nephritis followed for 5 to 30 years (median 127 months). Patients survival was 100% at 10 and 86% 20 years. The probability not reaching end point (persistent doubling plasma creatinine) 85% 72% A multivariate analysis variables presentation showed that male sex (P = 0.005) hematocrit lower than 36% 0.01) were associated (relative risk 7.5 14). then role renal flare-ups, defined either as a rapid increase in creatinine or by an proteinuria. flares any type had more probabilities who never 0.03; relative 6.8). hazard 27 times higher along increased without proteinuria alone < 0.00001). This when did return basal levels within two months after treatment