Endocytic Trafficking of the Notch Receptor

作者: Björn Schnute , Tobias Troost , Thomas Klein

DOI: 10.1007/978-3-319-89512-3_6

关键词:

摘要: The endosomal pathway plays an important role in several aspects of Notch signalling ranging from ligand-dependent to independent activation and also degradation the receptor. Here, we will focus on its during receptor describe with components that are for molecular machinery orchestrates these events. Subsequently, journey through system discuss genes involved. Mechanisms recently discovered ligand-independent be described contribution physiologically Notch-dependent processes discussed. Last but not least, summarize evidence vertebrates.

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