The associations of multiple metals mixture with accelerated DNA methylation aging.
作者： Lili Xiao , Gaohui Zan , Xiuming Feng , Yu Bao , Sifang Huang
DOI: 10.1016/J.ENVPOL.2020.116230
关键词:
摘要: Aging is a leading cause of mortality for the elderly and DNA methylation age is reported to be predictive of biological aging. However, few studies have investigated the associations between multiple metals exposure and accelerated aging in the elderly. We performed a pilot study of 288 elderly participants aged 50–115 years and measured genome-wide DNA methylation and 22 blood metals concentrations. Measures of DNA methylation age were estimated using CpGs from Illumina HumanMethylation EPIC BeadChip. Linear mixed …
sci-hub.st 参考文章(55)
Gregory A Wellenius, John J Godleski, Petros Koutrakis, Jennifer F Bobb, Murray A Mittleman, Brent A Coull, Marianthi-Anna Kioumourtzoglou, Part 1. Statistical Learning Methods for the Effects of Multiple Air Pollution Constituents. Research report (Health Effects Institute). pp. 5- 50 ,(2015)
Erika Brown, Paul B. Tchounwou, Clement G. Yedjou, Cytotoxicity and oxidative stress in human liver carcinoma cells exposed to arsenic trioxide (HepG(2)). Metal ions in biology and medicine : proceedings of the ... International Symposium on Metal Ions in Biology and Medicine held ... = Les ions metalliques en biologie et en medecine : ... Symposium international sur les ions metalliques .... ,vol. 10, pp. 583- 587 ,(2008)
Kristen E. Cosselman, Ana Navas-Acien, Joel D. Kaufman, Environmental factors in cardiovascular disease Nature Reviews Cardiology. ,vol. 12, pp. 627- 642 ,(2015) , 10.1038/NRCARDIO.2015.152
Steve Horvath, DNA methylation age of human tissues and cell types Genome Biology. ,vol. 14, pp. 3156- ,(2013) , 10.1186/GB-2013-14-10-R115
David Bernhard, Andrea Rossmann, Georg Wick, Metals in cigarette smoke. Iubmb Life. ,vol. 57, pp. 805- 809 ,(2005) , 10.1080/15216540500459667
Meaghan J. Jones, Sarah J. Goodman, Michael S. Kobor, DNA methylation and healthy human aging Aging Cell. ,vol. 14, pp. 924- 932 ,(2015) , 10.1111/ACEL.12349
Shaonly Samanta, Viswanath Swamy, D. Suresh, M. Rajkumar, Basabi Rana, Ajay Rana, Malay Chatterjee, Protective effects of vanadium against DMH-induced genotoxicity and carcinogenesis in rat colon: Removal of O6-methylguanine DNA adducts, p53 expression, inducible nitric oxide synthase downregulation and apoptotic induction Mutation Research-genetic Toxicology and Environmental Mutagenesis. ,vol. 650, pp. 123- 131 ,(2008) , 10.1016/J.MRGENTOX.2007.11.001
Dorina Podar, Michael H. Ramsey, Michael J. Hutchings, Effect of cadmium, zinc and substrate heterogeneity on yield, shoot metal concentration and metal uptake by Brassica juncea: implications for human health risk assessment and phytoremediation. New Phytologist. ,vol. 163, pp. 313- 324 ,(2004) , 10.1111/J.1469-8137.2004.01122.X
Peter J. Little, Runa Bhattacharya, Abel E. Moreyra, Irina L. Korichneva, Zinc and cardiovascular disease Nutrition. ,vol. 26, pp. 1050- 1057 ,(2010) , 10.1016/J.NUT.2010.03.007
Peter P Egeghy, James J Quackenboss, Sandra Catlin, P Barry Ryan, Determinants of temporal variability in NHEXAS-Maryland environmental concentrations, exposures, and biomarkers. Journal of Exposure Science and Environmental Epidemiology. ,vol. 15, pp. 388- 397 ,(2005) , 10.1038/SJ.JEA.7500415