Associations between birth and one year anthropometric measurements and IGF2 and IGF2R genetic variants in African American and Caucasian American infants

摘要: Insulin-like growth factor 2 receptor ( IGF2R ) and insulin-like IGF2 genetic variants have been inconsistently associated with low birth weight length in Caucasian Asian infants, however few studies included African Americans (AA). Generalized linear models logistic regression were used to examine associations between single nucleotide polymorphisms (SNP) rs629849 rs8191754, SNP rs680 infant anthropometric measurements, a racially diverse cohort Durham County, North Carolina. American (CA) carriers of the heavier P = 0.02) longer 0.003) at birth, body size age 1 yr was similar that AA. Birth significantly differed non-carriers variant both AA 0.04) CA infants 0.03). Both cm shorter compared non-carriers. We found no evidence for an association rs8191754 measurements. Associations SNPs one year gain only observed rs680; weighed less than 0.03); however, one. Larger using ancestral markers are required disentangle these associations.