Comorbidity of Severe Psychotic Disorders With Measures of Substance Use

摘要: Importance Although early mortality in severe psychiatric illness is linked to smoking and alcohol, our knowledge, no studies have comprehensively characterized substance use behavior psychotic illness. In particular, recent assessments of individuals with mental are based on population surveys that do not include Objective To compare the general population. Design, Setting, Participants We assessed comorbidity between disorders Genomic Psychiatry Cohort. The Cohort a clinically assessed, multiethnic sample consisting 9142 diagnosis schizophrenia, bipolar disorder features, or schizoaffective disorder, 10 195 control individuals. Main Outcomes Measures Smoking (smoked >100 cigarettes lifetime), heavy alcohol (>4 drinks/day), marijuana (>21 times use/year), recreational drug use. Results Relative population, increased risks for (odds ratio, 4.6; 95% CI, 4.3-4.9), 4.0; 3.6-4.4), 3.5; 3.2-3.7), 4.3-5.0). All races/ethnicities (African American, Asian, European Hispanic) both sexes greatly elevated marijuana, Of specific concern, public health efforts successfully decreased among younger than age 30 years appear been ineffective (interaction effect initiation, P  = 4.5 × 10 5 ). Conclusions Relevance largest assessment date, we found odds other be dramatically higher estimates mild