Preparation of surface-imprinted microspheres using ionic liquids as novel cross-linker for recognizing an immunostimulating peptide

摘要: Recently, the design and preparation of novel functional materials using biomimetic approaches for high adsorption precise selective capture biomolecules have been actively investigated. In this work, molecularly imprinted microspheres (MIMs) with a homogeneous polymer shell anchored onto SiO2 core particles were successfully synthesized via surface iniferter-initiated polymerization under room temperature in aqueous media. Herein, clinically relevant immunostimulating hexapeptide from human casein (IHHC) was chosen as template. Moreover, double imidazolium dicationic ionic liquid multiple binding sites used cross-linker to improve recognition performance enhance capacity MIMs simultaneously. The as-prepared characterized through various methods. Results revealed that not only exhibited excellent IHHC but also possessed synergistic effect directional non-directional interactions, which demonstrated their potential use practical application.