Improved amino acid sequences directed against il-6r and polypeptides comprising the same for the treatment of il-6r related diseases and disorders

摘要: The present invention relates to amino acid sequences that are directed against/and or can specifically bind Snterleukin-6 Receptor (IL-6R) with improved affinity and/or avidity, have an efficacy potency, and which capable of (partially, preferably totally) blocking the IL-6/IL-6R interaction inhibit signalization through IL-6, 1L-6R complex. further compounds constructs, in particular proteins polypeptides, comprise essentially consist one more such sequences. also nucleic acids encoding methods for preparing host ceils expressing compositions, pharmaceutical sequences, nucieic cells, uses acids, cells prophylactic, therapeutic diagnostic purposes.