Oxypyrimidines as syk modulators
作者： Zhaozhong J. Jia , Wolin Huang , Yonghong Song , Qing Xu , Anjali Pandey
DOI:
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摘要: The present invention is directed to compounds of formula (I) and tautomers thereof or pharmaceutically acceptable salts, esters, prodrugs which arc inhibitor Syk kinase. also intermediates used in making such compounds, the preparation a compound, pharmaceutical compositions containing methods inhibition kinase activity, platelet aggregation, prevent treat number conditions mediated at least part by as undesired thrombosis Non Hodgkin's Lymphoma.
google.it 参考文章(18)
Gaetan Ladouceur, Barton Phillips, Cheng Bi, Olaf Weber, James Cook, Yuanwei Chen, Jianqing Chen, Lin Yi, Sharad K. Verma, Stephen Boyer, Jianmei Fan, Jennifer Burke, Roger B. Clark, Chunguang Wang, Michael J. Burke, Dhanapalan Nagarathnam, 2- and 4-aminopyrimidines n-substtituded by a bicyclic ring for use as kinase inhibitors in the treatment of cancer ,(2002)
J. F. W. McOmie, Protective Groups in Organic Chemistry ,(2012)
Qingming Zhu, Wenlang Fu, Karl Miranda, Andrea Mcclure, Catherine Brennan, Jill E Wood, Donglei Liu, Brian Bear, Yuanwei Chen, Brent Chandler, Robert Sibley, Leatte Guernon, Donald Bierer, Lin Yi, Sharad Verma, Julie Dixon, Gang Chen, Jin Zhao, Chunguang Wang, Dhanapalan Nagarathnam, Michael Turner, 2-4-(di-phenyl-amino)-pyrimidine derivatives useful for treating hyper-proliferative disorders ,(2003)
Jerry March, Advanced Organic Chemistry: Reactions, Mechanisms, and Structure ,(1977)
Herbert Rudolf Treutlein, Marcel Robert Kling, Jun Zeng, Xianyong Bu, Andrew Frederick Wilks, Christopher John Burns, Michelle Leanne Styles, Selective Kinase Inhibitors ,(2005)
Ankush Argade, Somasekhar Bhamidipati, Jeffrey Clough, Holger Keim, Rajinder Singh, Hui Li, Catherine Sylvain, David Carroll, Methods of treating or preventing autoimmune diseases with 2,4-pyrimidinediamine compounds ,(2003)
Hiroyuki Hisamichi, Ryo Naito, Akira Toyoshima, Noriyuki Kawano, Atsushi Ichikawa, Akiko Orita, Masaya Orita, Noritaka Hamada, Makoto Takeuchi, Mitsuaki Ohta, Shin-ichi Tsukamoto, Synthetic studies on novel Syk inhibitors. Part 1: Synthesis and structure–activity relationships of pyrimidine-5-carboxamide derivatives Bioorganic & Medicinal Chemistry. ,vol. 13, pp. 4936- 4951 ,(2005) , 10.1016/J.BMC.2005.05.033
Susan Molineaux, Ankush Argade, Somasekhar Bhamidipati, Jeffrey Wayne Clough, Holger Keim, Donald G Payan, Rajinder Singh, Hui Li, Catherine Sylvain, Alexander B Rossi, Sasha J Holland, 2,4-pyrimidinediamine compounds and their uses ,(2003)
Douglas Mccord Sammond, Kristen Elizabeth Nailor, Neil W. Johnson, Holly Kathleen Emerson, Mui Cheung, Marcus Semones, Stanley Dawes Chamberlain, Diamino-pyrimidines and their use as angiogenesis inhibitors ,(2003)
Takahiro Miyake, Ichiro Umemura, Greg Chopiuk, Keiichi Masuya, Takanori Kanazawa, Nathanael Schiander Gray, Naoko Matsuura, Qiang Ding, Yongqin Wan, Qiong Zhang, Eiji Kawahara, Osamu Ohmori, Ruo Steensma, Donald Karanewsky, Carlos Garcia-Echeverria, Jiqing Jiang, 2, 4-pyrimidinediamines useful in the treatment of neoplastic diseases, inflammatory and immune system disorders ,(2004)