Biomass-based magnetic fluorescent nanoparticles: One-step scalable synthesis, application as drug carriers and mechanism study

摘要: Abstract A biomass-based magnetic fluorescent nanoparticle (MFNPs) was successively in situ synthesized via a one-step high-gravity approach, which constructed by core of Fe3O4 nanoparticles, the marker carbon dots (CDs), and shells chitosan (CS). The obtained MFNPs had 10 nm average diameter narrow particle size distribution, low cytotoxicity, superior emission superparamagnetic properties. encapsulating release 5-fluorouracil experiments confirmed that introduction CS/CDs effectively improved drug loading capacity. Mechanism kinetic studies proved that: (i) monolayer adsorption main sorption mode under studied conditions; (ii) whole process controlled intra-liquid diffusion mass transfer governed chemisorption; (iii) Fickian diffusion. These results demonstrated this method to continuously produce construction non-toxic nanostructure possessed great superiority currently Nano-delivery systems, would show high application value targeted delivery, fluid hyperthermia treatment, resonance imaging (MRI), vitro testing relative research.