Discovery of New Macrolides from Marine Organisms

作者: Masami Ishibashi

DOI: 10.1016/B978-012526451-8/50003-5

关键词:

摘要: Publisher Summary This chapter deals with the study of isolation and structure determination macrolides from marine organisms together their unique biological activities. Bacteria fungi that are isolated seawater media, sediments, or macro-organisms generally called microorganisms. Metabolites microorganisms sometimes exhibit structures very similar to those obtained terrestrial bacteria fungi. Most interesting activity play important roles as potential molecules for drug development tools basic sciences. The classifies numerous on basis which compounds isolated, includes description microorganisms, algae, sponges, other invertebrates. systematic investigation environments reveals a rich source bioactive including novel classes chemical structures, not found in resources.

参考文章(169)
Shigeki Matsunaga, Ping Liu, Cassandra A. Celatka, James S. Panek, Nobuhiro Fusetani, Relative and Absolute Stereochemistry of Mycalolides, Bioactive Macrolides from the Marine Sponge Mycale magellanica1 Journal of the American Chemical Society. ,vol. 121, pp. 5605- 5606 ,(1999) , 10.1021/JA990817W
Hirokazu Arimoto, Ichiro Hayakawa, Makoto Kuramoto, Daisuke Uemura, Absolute stereochemistry of halichlorine; A potent inhibitor of VCAM-1 induction Tetrahedron Letters. ,vol. 39, pp. 861- 862 ,(1998) , 10.1016/S0040-4039(97)10714-6
J. Mynderse, R. Moore, M Kashiwagi, T. Norton, Antileukemia activity in the Osillatoriaceae: isolation of Debromoaplysiatoxin from Lyngbya Science. ,vol. 196, pp. 538- 540 ,(1977) , 10.1126/SCIENCE.403608
Sarath P. Gunasekera, Malika Gunasekera, Ross E. Longley, Gayle K. Schulte, Discodermolide: a new bioactive polyhydroxylated lactone from the marine sponge Discodermia dissoluta The Journal of Organic Chemistry. ,vol. 55, pp. 4912- 4915 ,(1990) , 10.1021/JO00303A029
Yuko Kato, Nobuhiro Fusetani, Shiegeki Matsunaga, Kaneshisa Hashimoto, Ryuichi Sakai, Tatsuo Higa, Yoel Kashman, Antitumor macrodiolides isolated from a marine sponge theonella sp.: Structure revision of misakinolide A Tetrahedron Letters. ,vol. 28, pp. 6225- 6228 ,(1987) , 10.1016/S0040-4039(00)61853-1
ROSA ISABEL FERNÁNDEZ-CHIMENO, LIBRADA CAÑEDO, FERNANDO ESPLIEGO, DOLORES GRÁVALOS, FERNANDO DE LA CALLE, JOSÉ LUIS FERNÁNDEZ-PUENTES, FRÁNCISCO ROMERO, IB-96212, a novel cytotoxic macrolide produced by a marine Micromonospora. I. Taxonomy, fermentation, isolation and biological activities. The Journal of Antibiotics. ,vol. 53, pp. 474- 478 ,(2000) , 10.7164/ANTIBIOTICS.53.474
Michael R. Kernan, Tadeusz F. Molinski, D. John Faulkner, Macrocyclic antifungal metabolites from the spanish dancer nudibranch Hexabranchus sanguineus and sponges of the genus Halichondria Journal of Organic Chemistry. ,vol. 53, pp. 5014- 5020 ,(1988) , 10.1021/JO00256A021
Ruoli Bai, George F. Taylor, Zbigniew A. Cichacz, Cherry L. Herald, John A. Kepler, George R. Pettit, Ernest Hamel, The spongistatins, potently cytotoxic inhibitors of tubulin polymerization, bind in a distinct region of the vinca domain. Biochemistry. ,vol. 34, pp. 9714- 9721 ,(1995) , 10.1021/BI00030A009
Emilio Quinoa, Yao Kakou, Phillip Crews, Fijianolides, polyketide heterocycles from a marine sponge Journal of Organic Chemistry. ,vol. 53, pp. 3642- 3644 ,(1988) , 10.1021/JO00250A052
Nobuaki Matsumori, Daisuke Kaneno, Michio Murata, Hideshi Nakamura, Kazuo Tachibana, Stereochemical Determination of Acyclic Structures Based on Carbon−Proton Spin-Coupling Constants. A Method of Configuration Analysis for Natural Products Journal of Organic Chemistry. ,vol. 64, pp. 866- 876 ,(1999) , 10.1021/JO981810K