摘要: The field of hepatotoxicity owes much to the contributions Dr. Hyman J. Zimmerman. publication his monograph, Hepatotoxicity: Adverse Effects Drugs and Other Chemicals on Liver in 1978 was eagerly awaited. Affectionately known as Bible hepatotoxicity, it represented nearly three decades study observations every clinical experimental aspect drug-induced hepatic injury. Virtually all classes medicinal agents a multitude chemicals environmental toxins are capable causing acute injury liver. spectrum lesions produced by these drugs is diverse, mimicking most infectious, inflammatory, vascular, neoplastic disorders. While discussion each agent beyond scope this chapter, I nevertheless endeavor provide an overview various aspects liver disease. For information particular agents, reader urged consult Zimmerman’s textbook1 or any number reference works.2–4
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