Evidence for two genetic loci in Yersinia enterocolitica that can promote invasion of epithelial cells.

作者: V L Miller , S Falkow

DOI: 10.1128/IAI.56.5.1242-1248.1988

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摘要: Virulent strains of Yersinia enterocolitica cause disease syndromes ranging from mild gastroenteritis to lymphadenitis and septicemia. The ability these bacteria invade intestinal epithelial cells gain access the reticuloendothelial system is thought be an important aspect their virulence. We report here on cloning two Y. chromosomal loci, inv ail, each which confers invasive phenotype Escherichia coli HB101. locus allows a uniformly high level invasion in several tissue culture lines homologous gene pseudotuberculosis. second locus, shows more host specificity than that it variable degree some cell (e.g., HEp-2, HEC1B, CHO cells) but no others Madin-Darby canine kidney cells). Images

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