Socioeconomic status during lifetime and cognitive impairment no-dementia in late life: the population-based aging in the Chianti Area (InCHIANTI) Study.

摘要: Thousand and twelve dementia-free elderly (60-98 years old) enrolled in the InChianti Study (Italy) were evaluated at baseline (1998-2000) 3-year follow-up (2001-2003) with aim of analyzing association lifetime socioeconomic status (SES) prevalent incident cognitive impairment no-dementia (CIND). SES was defined from information on formal education, longest held occupation, financial conditions through life. CIND as age-adjusted Mini-Mental State Examination score one standard deviation below mean participants without dementia. Logistic regression Cox proportional-hazards models used to estimate CIND. Demographics, occupation characteristics (i.e., job stress physical demand), cardiovascular diseases, diabetes, apolipoprotein E (APOE) genotype, smoking, alcohol consumption, depressive symptoms, C-reactive protein considered potential confounders. Prevalence 17.7%. In fully adjusted model, low education (OR = 2.1; 95% confidence intervals, CI 1.4 3.2) associated Incidence rate 66.0 per 1000 person-years. Low (HR 1.7; 1.04 2.6) manual 1.9; 1.0 3.6) Among covariates, high job-related demand both 1.6; 1.1 2.4 HR 1.5; 2.3). After stratification for still among 2.2; 1.2 4.3 versus 1.4; 0.2 10.4 those education). Proxy markers (low demand) are cross-sectional correlates predict over a three-year follow-up.