IκB kinase β (IKKβ/IKK2/IKBKB)—A key molecule in signaling to the transcription factor NF-κB

作者: Johannes A. Schmid , Andreas Birbach

DOI: 10.1016/J.CYTOGFR.2008.01.006

关键词:

摘要: IKKβ/IKBKB (IκB kinase beta), also designated as IKK2, was named after its function of phosphorylating IκB molecules, the inhibitors of NF-κB transcription factors. The kinase activity of …

参考文章(93)
M S Hayden, A P West, S Ghosh, NF-kappaB and the immune response. Oncogene. ,vol. 25, pp. 6758- 6780 ,(2006) , 10.1038/SJ.ONC.1209943
Toby Lawrence, Magali Bebien, George Y. Liu, Victor Nizet, Michael Karin, IKKα limits macrophage NF-κB activation and contributes to the resolution of inflammation Nature. ,vol. 434, pp. 1138- 1143 ,(2005) , 10.1038/NATURE03491
Jianhua Yang, Yong Lin, Zijian Guo, Jinke Cheng, Jianyi Huang, Li Deng, Warren Liao, Zhijian Chen, Zheng-gang Liu, Bing Su, The essential role of MEKK3 in TNF-induced NF-κB activation Nature Immunology. ,vol. 2, pp. 620- 624 ,(2001) , 10.1038/89769
N D Perkins, T D Gilmore, Good cop, bad cop: the different faces of NF-κB Cell Death & Differentiation. ,vol. 13, pp. 759- 772 ,(2006) , 10.1038/SJ.CDD.4401838
Lin-Feng Chen, Warner C. Greene, Shaping the nuclear action of NF-κB Nature Reviews Molecular Cell Biology. ,vol. 5, pp. 392- 401 ,(2004) , 10.1038/NRM1368
T. T. Huang, N. Kudo, M. Yoshida, S. Miyamoto, A nuclear export signal in the N-terminal regulatory domain of IκBα controls cytoplasmic localization of inactive NF-κB/IκBα complexes Proceedings of the National Academy of Sciences of the United States of America. ,vol. 97, pp. 1014- 1019 ,(2000) , 10.1073/PNAS.97.3.1014
Fan Yang, Eric Tang, Kunliang Guan, Cun-Yu Wang, IKKβ Plays an Essential Role in the Phosphorylation of RelA/p65 on Serine 536 Induced by Lipopolysaccharide Journal of Immunology. ,vol. 170, pp. 5630- 5635 ,(2003) , 10.4049/JIMMUNOL.170.11.5630
Min-Jean Yin, Yumi Yamamoto, Richard B. Gaynor, The anti-inflammatory agents aspirin and salicylate inhibit the activity of IκB kinase-β Nature. ,vol. 396, pp. 77- 80 ,(1998) , 10.1038/23948
Chen Wang, Li Deng, Mei Hong, Giridhar R Akkaraju, Jun-ichiro Inoue, Zhijian J Chen, None, TAK1 is a ubiquitin-dependent kinase of MKK and IKK Nature. ,vol. 412, pp. 346- 351 ,(2001) , 10.1038/35085597