Synchrotron radiation in the biosciences

摘要: List of contributors. Part I: Crystallographic studies on macromolecular structure. 1.1: Recent developments in structure by X-ray crystallography. 1.2: Time-resolved 1.3: Protein crystallography Japan. 1.4: Experience the measurement and analysis multiwavelength anomalous dispersion data from crystals. 1.5: Electrostatic interactions conformational variability cubic insulin 1.6: Crystal structural tobacco necrosis virus (TNV). 1.7: Cryocrystallography native derivatized ribosomal 1.8: Structure function glutathione synthetase Escherichia coli B. 1.9: analyses exploiting collection efficiency precision provided macromolecule-oriented Weissenberg camera installed at Beamline 6A2 Photon Factory, Tsukuba. 1.10: carbonic anhydrase: synchrotron diffraction human anhydrase I inhibitor complexes. 1.11: study hydrogenase related proteions sulfate-reducing bacteria. 1.12: 'Pivot hypothesis': a signalling mechanism bacterial chemotaxis receptor. 1.13: Fast as an altrnative to Laue method kinetic 2: More information time-dependent solution scattering. 2.1: Solution 2.2: scattering allosteric transition aspartate transcarbamylase. 2.3: The effect point mutations changes enzyme transcarbamylase coli. 2.4: Dynamics microtubules stochastic switching periodic swinging. 2.5: Synchrotron radiation cryo electron microscopy vinblastine-induced polymers purified tubulin: evaluation effects magnesium concentration temperature. 2.6: Expression calmodulin: interaction between calmodulin fragment mastoparan. 2.7: Use for protein folding study. 2.8: High-resolution small-angle multilamellar phospholipid systems. 2.9: Temperature-jump relaxation phospholipids: intermediates memory phase transitions. 3: Biology with neutron radiation. 3.1: Neutrons biology - complementarity X-rays. 3.2: Hydrogen bonding solvent proteins. 3.3: Neutron Ca2+-binding proteins their regulatory targets: comparisons troponin C calmodulin. 3.4: Characteristic phosphatidylinositol diphosphate (PIP2) complex bovine serum albumin water PIP2 bilayers. 4: biological absorption fine-structure spectroscopy. 4.1: Sensitive rapid 4.2: spectroscopy using high-brilliance photon sources. 4.3: some metalloproteins. 4.4: A model photosynthetic oxygen-evolving manganese complex. 4.5: fine paramagnetic resonance molecular electronic state Mn cluster water-splitting enzyme. 4.6: geminate states myoglobin CO near-edge 4.7: structure-function relationship active sites haemoprotein catalysis. 4.8: Soft magnetic dichroism biology. 5: beamlines detectors. 5.1: sciences 5.2: Diffraction diffuse biophysical applications ESRF. 5.3: Developments gas detectors biophysics Daresbury SRS. 5.4: television 5.5: development Factory. 6: Structural muscle protein, contraction, filamentous virus. 6.1: What X-rays tell us about contraction then now. 6.2: DNase binding induces change actin monomer. 6.3: activation myosin head motions frog sartorius during isotonic isometric contraction. 6.4: evidence specific actomyosin live isometrically contracting muscle. 6.5: Modelling thin filaments 6.6: time-resolved movements 6.7: Frequency dependence variation pattern tetanized skeletal sinusoidal length changes. 6.8: experiments various types vertebrate 6.9: Application contractile apparatus single intact fibres. 6.10: crossbridges induced photolysis caged ATP: 6.11: detected 6.12: field around filament. 6.13: molluscan smooth 6.14: Muscle Cornell High Energy Source. 6.15: Fibre viruses. 7: microimaging. 7.1: Natural imaging specimens microscopes. 7.2: National Light 7.3: microscopy: present status future prospects. 7.4: contact chromosome 7.5: Macromolecular transport zymogen granule measured quantitative X-ray. 7.6: multilayer mirrors: MAXIMUM photoelectron microscope. 7.7: zooming tube microscopy. 7.8: Hard scanning micro iron compounds enameloid fish teeth. 7.9: Microscopy Resource Center Advanced 8: Medical radiation: angiography, computerized tomography, others. 8.1: coronary angiography humans. 8.2: Digital subtraction Russia. 8.3: K-edge system dual linearly polarized beams ellipsoid multipole wiggler. 8.4: Coronary Hamburger Synchrotronstrahlungslabor (HASYLAB). 8.5: 9: Radiation 9.1: radiobiology 9.2: use synchrotron-produced ultrasoft radiobiological processes. 9.3: inner cell ionization/excitation. 9.4: damage free nucleotides sulfur-containing amino acids monoenergetic 9.5: DNA monochromatic photons 9.6: Ultraviolet free-electron laser facility Brookhaven Laboratory. 9.7: Biological effectiveness low-energy electrons revealed soft 9.8: Strand breaks buffered K-shell edge phosphorus. 9.9: Action spectra inactivation mutagenesis Bacillus subtilis spores wavelength ranges 0.1 300 nm