The human papillomavirus type 16 E6 and E7 oncoproteins independently induce numerical and structural chromosome instability.
作者： Karl Münger , Stefan Duensing
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摘要: The development of genomic instability is a hallmark of high-risk human papillomavirus (HPV) associated cervical carcinogenesis. We have previously shown that the HPV-16 E7 …
aacrjournals.org参考文章(51)
Fred Bunz, Annie Dutriaux, Kenneth W Kinzler, Christine Fauth, John M Sedivy, Michael R Speicher, Bert Vogelstein, Christoph Lengauer, Targeted inactivation of p53 in human cells does not result in aneuploidy. Cancer Research. ,vol. 62, pp. 1129- 1133 ,(2002)
T. Weinert, CELL CYCLE: Enhanced: A DNA Damage Checkpoint Meets the Cell Cycle Engine Science. ,vol. 277, pp. 1450- 1451 ,(1997) , 10.1126/SCIENCE.277.5331.1450
Christoph Lengauer, Kenneth W. Kinzler, Bert Vogelstein, Genetic instabilities in human cancers Nature. ,vol. 396, pp. 643- 649 ,(1998) , 10.1038/25292
Irene M. Ward, Junjie Chen, Histone H2AX Is Phosphorylated in an ATR-dependent Manner in Response to Replicational Stress Journal of Biological Chemistry. ,vol. 276, pp. 47759- 47762 ,(2001) , 10.1074/JBC.C100569200
Anette Duensing, Christopher P. Crum, Karl Münger, Stefan Duensing, Human papillomavirus type 16 E7 oncoprotein-induced abnormal centrosome synthesis is an early event in the evolving malignant phenotype. Cancer Research. ,vol. 61, pp. 2356- 2360 ,(2001)
David E. Wazer, Vimla Band, Sarah N. Boyer, E7 Protein of Human Papilloma Virus-16 Induces Degradation of Retinoblastoma Protein through the Ubiquitin-Proteasome Pathway Cancer Research. ,vol. 56, pp. 4620- 4624 ,(1996)
Shirley A. Southern, Mark F. Evans, C. Simon Herrington, Basal Cell Tetrasomy in Low-Grade Cervical Squamous Intraepithelial Lesions Infected with High-Risk Human Papillomaviruses Cancer Research. ,vol. 57, pp. 4210- 4213 ,(1997)
Barbara McClintock, The Stability of Broken Ends of Chromosomes in Zea Mays. Genetics. ,vol. 26, pp. 234- 282 ,(1941)
C L Halbert, G W Demers, D A Galloway, The E6 and E7 genes of human papillomavirus type 6 have weak immortalizing activity in human epithelial cells. Journal of Virology. ,vol. 66, pp. 2125- 2134 ,(1992) , 10.1128/JVI.66.4.2125-2134.1992
W. L. Lingle, S. L. Barrett, V. C. Negron, A. B. D'Assoro, K. Boeneman, W. Liu, C. M. Whitehead, C. Reynolds, J. L. Salisbury, Centrosome amplification drives chromosomal instability in breast tumor development. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 99, pp. 1978- 1983 ,(2002) , 10.1073/PNAS.032479999