A systematic review and meta-analysis suggests obesity predicts onset of chronic kidney disease in the general population

摘要: Obesity and chronic kidney disease (CKD) are public health priorities that share core pathophysiological mechanisms. However, whether high body mass index (BMI) increases risk of CKD de novo remains ill-defined. To evaluate the role BMI in predicting onset general adult population, we performed a systematic review meta-analysis PubMed ISI Web Science databases articles published between January 2000 August 2016 without language restriction. We selected studies individuals from population with normal renal function at baseline reported low estimated glomerular filtration (eGFR) (under 60 mL/min/1.73m 2 ) and/or albuminuria (1+ dipstick or an albumin creatinine ratio 3.4 mg/mmol more) as hazard ratio, odds relative related to obesity, overweight, continuous value. A total 39 cohorts covering 630, 677 participants mean follow-up 6.8 years were selected. increased risk, 95% confidence interval heterogeneity (I developing eGFR (1.28, 1.07–1.54, [I : 95.0%]) (1.51, 1.36–1.67, 62.7%]). Increase unit was also associated higher (1.02, 1.01–1.03, : 24.3%]) 1.00–1.04, 0%]). Conversely, overweight did not predict either (1.06, 0.94–1.21, 50.0%]) (1.24, 0.98–1.58, 49.4%]). Thus, predicts failure (CKD stages 1–2) as well 3 higher, effect being significant only obese individuals. Hence, our findings may have implications improve stratification recommendations on weight control population.