Diabetic Cardiomyopathy: Role of the E3 Ubiquitin Ligase
作者： Tao Bai , Fan Wang , Nicholas Mellen , Yang Zheng , Lu Cai
DOI: 10.1152/AJPENDO.00467.2015
关键词:
摘要: Diabetic cardiomyopathy (DCM) is the leading cause of mortality in diabetes. As number cases diabetes continues to rise, it urgent develop new strategies protect against DCM, which characterized by cardiac hypertrophy, increased apoptosis, fibrosis, and altered insulin metabolism. The E3 ubiquitin ligases (E3s), one component ubiquitin-proteasome system, play vital roles all features DCM listed above. They also modulate activity several transcription factors involved pathogenesis DCM. In addition, E3s degrade both receptor substrates regulate gene transcription, resistance deficiency. Therefore, may be a driving force for This review summarizes currently available studies analyze enriches our knowledge how develops, provides novel strategy heart from
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