Vagus nerve stimulation reverses ventricular electrophysiological changes induced by hypersympathetic nerve activity

摘要: New Findings What is the central question of this study? Previous studies have shown that hypersympathetic nerve activity results in ventricular electrophysiological changes and facilitates occurrence arrhythmias. Vagus stimulation has therapeutic potential for myocardial infarction-induced However, actions vagus on activity-induced are still unknown. What main finding its importance? We show able to reverse suppress fibrillation. These findings further suggest may be an effective treatment option arrhythmias, especially patients with infarction or heart failure. Vagus (VNS) This study aimed investigate effects VNS induced by activity. Seventeen open-chest dogs were subjected left stellate ganglion (LSGS) 4 h simulate tone. All animals randomly assigned group (n = 9) control (n = 8). In group, was performed at voltage causing a 10% decrease rate hours 3–4 during LSGS. During first 2 h LSGS, refractory period (ERP) action duration (APD) both progressively significantly decreased; spatial dispersion ERP, maximal slope restitution curve pacing cycle length APD alternans all increased. With LSGS + VNS next 2 h, there significant return altered parameters towards baseline levels. eight received LSGS without VNS, changed progressively, but any reversals. The fibrillation threshold higher than (17.3 ± 3.4 versus 11.3 ± 3.8 V, P < 0.05). present demonstrated LSGS-induced