Electrodynamic investigations of ion transport and structural properties in drug-containing gels: dielectric spectroscopy and transient current measurements on catanionic carbopol systems.

摘要: The aim of this study is to show the potential using electrodynamic methods as characterization tools in controlled drug release process, on complex systems. two formulations under were a Carbopol gel containing diphenhydramine and an identical also surfactant sodium dodecyl sulfate which forms catanionic vesicles with diphenhydramine. average diffusion coefficients calculated from both dielectric spectroscopy transient current measurements. Comparing herein-obtained those obtained another traditional USP technique for same system, values are virtually same. proved be potentially valuable obtaining information about concentration motion molecules inside gel. measurements particularly interesting case, method gives not only level, but different charged moieties separately. Interestingly, it seems that applicable mesh size