Colorectal Cancer, Systemic Inflammation, and Outcome: Staging the Tumor and Staging the Host

摘要: Objective: This study aims to examine the clinical utility of combination TNM stage and modified Glasgow Prognostic Score (mGPS) in patients undergoing potentially curative resection colorectal cancer (CRC). Background: Of measures systemic inflammatory response, mGPS has been most extensively validated with cancer. Methods: Data from 1000 consecutive CRC a single institution (January 1997–May 2013) were included. The relationship between [0–C-reactive protein (CRP) ≤ 10 mg/L, 1—CRP > mg/L albumin ≥35 g/L, 2—CRP 35 g/L], stage, cancer-specific survival (CSS) overall (OS) was examined using Kaplan-Meier log-rank analysis multivariate Cox regression analysis. Results: An 0, 1, 2 observed 63%, 21%, 16% patients, respectively. Median follow-up 56 months (interquartile range: 28–107 months). independently associated CSS OS (all P < 0.001). In all stratified 5-year 97% 87% (stage I, = 0) 32% 26% III, 2), elective colon (n 575), ranged 100% 37% 30% respectively. Conclusions: shows how effectively stratifies outcome CRC. These data support routine staging both tumor host