A pleiotropic model of phenotypic evolution

摘要: A pleiotropic model is presented for deriving the equilibrium genetic variance by mutation and stabilizing selection long-term responses to directional in case where mutations have effects on fitnes itself (direct deleterious effect) a quantitative trait (phenotypic effect). The derived as general form of rare-alleles models, i.e., \({\tilde V_G} = \frac{{2n\mu {\alpha ^2}}}{{{s_u} + ^2}/(2{V_s})}}\) n number loci, μ per-locus rate, α2 new mutations, V s measure selection, u coefficient direct effect. calculated based assumption that kept at an but without starts operate target trait. evolutionary rate atiunm t-th generation after introduction \(\Delta \bar z(t) i{\tilde V_G}{e^{ - {s_T}t}}\) i intensity, S T total α2/(2V ). limit R iV m /s 2 Vm mutational (2nμα2). genes reduce both