Electrophysiological and Contractile Effects of Disopyramide in Patients With Obstructive Hypertrophic Cardiomyopathy: A Translational Study.
作者： Leonardo Sacconi , Pierluigi Stefàno , Laura Flink , Katherine Riedy , Francesco Saverio Pavone
DOI: 10.1016/J.JACBTS.2019.06.004
关键词:
摘要: Disopyramide is effective and safe in patients with obstructive hypertrophic cardiomyopathy. However, its cellular molecular mechanisms of action are unknown. We tested disopyramide cardiomyocytes from the septum surgical myectomy patients: inhibits multiple ion channels, leading to lower Ca transients force, shortens potentials, thus reducing arrhythmias. The electrophysiological profile explains efficient reduction outflow gradients but also limited prolongation QT interval absence arrhythmic side effects observed 39 disopyramide-treated patients. In conclusion, our results support idea that for outpatient use
onlinejacc.org 参考文章(54)
P. Honerjäger, The contribution of Na channel block to the negative inotropic effect of antiarrhythmic drugs. Basic Research in Cardiology. pp. 33- 37 ,(1986) , 10.1007/978-3-662-11374-5_4
Eleonora Savio-Galimberti, Björn C. Knollmann, Channel Activity of Cardiac Ryanodine Receptors (RyR2) Determines Potency and Efficacy of Flecainide and R-Propafenone against Arrhythmogenic Calcium Waves in Ventricular Cardiomyocytes PLOS ONE. ,vol. 10, ,(2015) , 10.1371/JOURNAL.PONE.0131179
M Sacherer, S Sedej, P Wakuła, M Wallner, MA Vos, J Kockskämper, P Stiegler, M Sereinigg, D von Lewinski, G Antoons, BM Pieske, FR Heinzel, , JTV519 (K201) reduces sarcoplasmic reticulum Ca2+ leak and improves diastolic function in vitro in murine and human non‐failing myocardium British Journal of Pharmacology. ,vol. 167, pp. 493- 504 ,(2012) , 10.1111/J.1476-5381.2012.01995.X
Elisa Passini, Ana Mincholé, Raffaele Coppini, Elisabetta Cerbai, Blanca Rodriguez, Stefano Severi, Alfonso Bueno-Orovio, Mechanisms of pro-arrhythmic abnormalities in ventricular repolarisation and anti-arrhythmic therapies in human hypertrophic cardiomyopathy Journal of Molecular and Cellular Cardiology. ,vol. 96, pp. 72- 81 ,(2016) , 10.1016/J.YJMCC.2015.09.003
Raffaele Coppini, Cecilia Ferrantini, Luca Mazzoni, Laura Sartiani, Iacopo Olivotto, Corrado Poggesi, Elisabetta Cerbai, Alessandro Mugelli, Regulation of intracellular Na(+) in health and disease: pathophysiological mechanisms and implications for treatment. Global Cardiology Science and Practice. ,vol. 2013, pp. 222- 242 ,(2013) , 10.5339/GCSP.2013.30
Mark Sherrid, Ernest Delia, Edward Dwyer, Oral disopyramide therapy for obstructive hypertrophic cardiomyopathy The American Journal of Cardiology. ,vol. 62, pp. 1085- 1088 ,(1988) , 10.1016/0002-9149(88)90553-X
Wen-Teh Chiang, Christer von Bahr, Berit Calissendorff, Rune Dahlqvist, Håkan Emilsson, Anita Magnusson, Karin Schenck-Gustafsson, Kinetics and dynamics of disopyramide and its dealkylated metabolite in healthy subjects Clinical Pharmacology and Therapeutics. ,vol. 38, pp. 37- 44 ,(1985) , 10.1038/CLPT.1985.131
Mark V. Sherrid, Ivan Barac, William J. McKenna, Perry M. Elliott, Shaughan Dickie, Lidia Chojnowska, Susan Casey, Barry J. Maron, Multicenter study of the efficacy and safety of disopyramide in obstructive hypertrophic cardiomyopathy Journal of the American College of Cardiology. ,vol. 45, pp. 1251- 1258 ,(2005) , 10.1016/J.JACC.2005.01.012
Sanda Despa, Donald M. Bers, Na+ transport in the normal and failing heart — Remember the balance Journal of Molecular and Cellular Cardiology. ,vol. 61, pp. 2- 10 ,(2013) , 10.1016/J.YJMCC.2013.04.011
Sandeep Joshi, Utpal K. Patel, Siu-Sun Yao, Vilma Castenada, April Isambert, Glenda Winson, Farooq A. Chaudhry, Mark V. Sherrid, Standing and Exercise Doppler Echocardiography in Obstructive Hypertrophic Cardiomyopathy: The Range of Gradients with Upright Activity Journal of The American Society of Echocardiography. ,vol. 24, pp. 75- 82 ,(2011) , 10.1016/J.ECHO.2010.10.006