Transmissible microbial and metabolomic remodeling by soluble dietary fiber improves metabolic homeostasis

摘要: Dietary fibers are increasingly appreciated as beneficial nutritional components. However, a requisite role of gut microbiota in fiber function and the overall impact on metabolomic flux remain unclear. We herein showed enhancing effects soluble resistant maltodextrin (RM) glucose homeostasis mouse metabolic disease models. Remarkably, fecal transplantation (FMT) caused pronounced time-dependent improvement tolerance RM recipient mice, indicating causal relationship between microbial remodeling efficacy. Microbial 16S sequencing revealed transmissible taxonomic changes correlated with improved metabolism, notably enrichment probiotics reduction Alistipes Bacteroides known to associate high fat/protein diets. Metabolomic profiling further illustrated broad changes, including phenylpropionates decreases key intermediates utilization, cholesterol biosynthesis amino acid fermentation. These studies elucidate roles RM-dependent homeostasis, showcase prevalent health-promoting potentials dietary fibers.