Effect of chronic psychosocial stress on nonalcoholic steatohepatitis in mice.

摘要: Nonalcoholic fatty liver disease (NAFLD) is characterized by hepatic lipid accumulation which may progress towards inflammation (nonalcoholic steatohepatitis (NASH)). NAFLD regarded as a consequence of sedentary, food-abundant lifestyle which, in the modern world, often coincides with chronically high levels perceived psychosocial stress. Here, we aimed to characterize effect chronic stress on development NAFLD/NASH male mice either fed standard chow or NASH-inducing fat diet. Chronic was induced subordinate colony housing (CSC), pre-clinically validated paradigm relevant for human affective and somatic disorders. Single housed (SHC) served controls. Under conditions CSC revealed lower triglyceride but higher TNFα, MCP-1 HMOX mRNA expression, while serum transaminase did not significantly differ from SHC mice. high-fat diet showed similar body weight-gain glucose adiponectin. Moreover, histology well expression were HFD. Surprisingly, even than same Together, these data indicate that under normal dietary model induces noticeable oxidative without causing manifest hepatocellular injury. In contrast, exhibited protective injury NASH-model. Identification underlying mechanisms this phenomenon lead novel therapeutic strategies prevent progression NAFLD.