Rational design of potent antagonists to the human growth hormone receptor.
作者： J. A. Wells , G. Fuh , B. C. Cunningham , R. Fukunaga , S. Nagata
DOI: 10.1126/SCIENCE.256.5064.1677
关键词:
摘要: … A hybrid receptor was constructed that contained the extracellular binding domain of the human growth hormone (hGH) receptor linked to the transmembrane and intracellular domains …
sciencemag.org
harvard.edu
researchgate.net 参考文章(19)
R Barnard, P G Bundesen, D B Rylatt, M J Waters, Evidence From the Use of Monoclonal-Antibody Probes for Structural Heterogeneity of the Growth-Hormone Receptor Biochemical Journal. ,vol. 231, pp. 459- 468 ,(1985) , 10.1042/BJ2310459
R. Fukunaga, E. Ishizaka-Ikeda, S. Nagata, Purification and characterization of the receptor for murine granulocyte colony-stimulating factor. Journal of Biological Chemistry. ,vol. 265, pp. 14008- 14015 ,(1990) , 10.1016/S0021-9258(18)77449-8
G Fuh, M G Mulkerrin, S Bass, N McFarland, M Brochier, J H Bourell, D R Light, J A Wells, The human growth hormone receptor. Secretion from Escherichia coli and disulfide bonding pattern of the extracellular binding domain. Journal of Biological Chemistry. ,vol. 265, pp. 3111- 3115 ,(1990) , 10.1016/S0021-9258(19)39741-8
R. Fukunaga, E. Ishizaka-Ikeda, C.X. Pan, Y. Seto, S. Nagata, Functional domains of the granulocyte colony-stimulating factor receptor The EMBO Journal. ,vol. 10, pp. 2855- 2865 ,(1991) , 10.1002/J.1460-2075.1991.TB07835.X
B. C. Cunningham, J. A. Wells, Rational design of receptor-specific variants of human growth hormone. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 88, pp. 3407- 3411 ,(1991) , 10.1073/PNAS.88.8.3407
LAWRENCE A. FROHMAN, Clinical review 22: Therapeutic options in acromegaly. The Journal of Clinical Endocrinology and Metabolism. ,vol. 72, pp. 1175- 1181 ,(1991) , 10.1210/JCEM-72-6-1175
B. Cunningham, D. Henner, J. Wells, Engineering human prolactin to bind to the human growth hormone receptor. Science. ,vol. 247, pp. 1461- 1465 ,(1990) , 10.1126/SCIENCE.2321008
A. de Vos, M Ultsch, A. Kossiakoff, Human growth hormone and extracellular domain of its receptor: crystal structure of the complex. Science. ,vol. 255, pp. 306- 312 ,(1992) , 10.1126/SCIENCE.1549776
T. A. Kunkel, Rapid and efficient site-specific mutagenesis without phenotypic selection. Proceedings of the National Academy of Sciences of the United States of America. ,vol. 82, pp. 488- 492 ,(1985) , 10.1073/PNAS.82.2.488
David Cosman, Stewart D. Lyman, Rejean L. Idzerda, M.Patricia Beckmann, Linda S. Park, Raymond G. Goodwin, Carl J. March, A new cytokine receptor superfamily Trends in Biochemical Sciences. ,vol. 15, pp. 265- 270 ,(1990) , 10.1016/0968-0004(90)90051-C