Use of isosulfan blue for identification of lymphatic vessels: experimental and clinical evaluation

摘要: Use of vital dyes for identification lymphatic vessels before cannulation has heretofore not been approved by the Food and Drug Administration (FDA). The suitability isosulfan blue, 2,5 disulfonic acid isomer Patent Blue, this purpose was evaluated experimentally in rat clinically 11 volunteers 543 patients under an investigational new drug application. FDA approval obtained. Volunteers received up to 15 mg a 1% sterile, pyrogen-free solution per extremity (total dose 0.4 mg/kg average patient). Excellent achieved 100% 97.4% patients. In other 2.6%, were identified mainly due congenital vascular (Milroy) disease. Baseline blood chemistry altered after administration dye. No adverse reactions found minimal allergic occurred less than Acute tox...