Polypeptide Nanogels With Different Functional Cores Promote Chemotherapy of Lung Carcinoma.
作者： Kai Niu , Nan Li , Yunming Yao , Chunjie Guo , Yuanyuan Ge
关键词:
摘要: Two kinds of tumor microenvironment-responsive polypeptide nanogels were developed for intracellular delivery cytotoxics to enhance the antitumor efficacies and reduce side effects in chemotherapy lung carcinoma. The sizes both DOX-loaded methoxy poly(ethylene glycol)−poly(L-phenylalanine-co-L-cystine) (mPEG−P(LP-co-LC)) glycol)−poly(L-glutamic acid-co-L-cystine) (mPEG−P(LG-co-LC)) (NGP/DOX NGG/DOX) less than 100 nm, which was appropriate enhanced permeability retention (EPR) effect. loading stable neutral environment while quickly degraded mimic microenvironment. Furthermore, reduction-responsive showed significantly higher cell uptake free DOX·HCl as time went on from 2 6 h. In addition, these efficient vivo, verified by obviously increased necrosis areas tissues. efficiently reduced DOX. conclusion, polypeptides based are suitable therapy
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