Changes in neuronal DNA content variation in the human brain during aging

摘要: The human brain has been proposed to represent a genetic mosaic, containing small but constant number of neurons with an amount DNA exceeding the diploid level that appear be generated through various chromosome segregation defects initially. While portion these cells apparently die during development, abnormal chromosomal copy have identified in mature brain. This genomic alteration might lead instability affecting neuronal viability and could thus contribute age-related mental disorders. Changes frequency such structural variation adult aging brain, however, are unknown. Here, we quantified more than content cerebral cortex normal analyzed its changes between fourth ninth decades life. We applied protocol slide-based cytometry optimized for quantification single neurons, which allowed analyze about 500 000 each On average, 11.5% cortical showed above level. this was highest at younger age declined age. Our results indicate associated compromise susceptibilities CNS Alternatively, potential selection bias "healthy brains" needs considered, assuming certain threshold associates Alzheimer's disease.