Enhanced transport using membrane disruptive agents

摘要: Compositions and methods for transport or release of therapeutic diagnostic agents metabolites other analytes from cells, compartments within through cell layers barriers are described. The compositions include a membrane barrier enhancing agent usually administered in combination with an enhancer and/or exposure to stimuli effect disruption altered permeability, release. In preferred embodiment, the compounds which disrupt endosomal membranes response low pH endosomes but relatively inactive toward membranes, coupled directly indirectly agent. Other disruptive can also be used, responsive enhancers than pH, such as light, electrical stimuli, electromagnetic ultrasound, temperature, combinations thereof. by ionic, covalent H bonds delivered ligand forms complex delivered. Agents agents. Treatments enhance delivery iontopheresis, electropheresis used disrupting