Dementia with Lewy bodies: an update and outlook

摘要: Dementia with Lewy bodies (DLB) is an age-associated neurodegenerative disorder producing progressive cognitive decline that interferes normal life and daily activities. Neuropathologically, DLB characterised by the accumulation of aggregated α-synuclein protein in neurites, similar to Parkinson’s disease (PD). Extrapyramidal motor features characteristic PD, are common patients, but not essential for clinical diagnosis DLB. Since many PD patients develop dementia as progresses, there has been controversy about separation from (PDD) consensus reports have put forward guidelines assist clinicians identification management both syndromes. Here, we present basic concepts definitions, based on our current understanding, should guide community address open questions will, hopefully, lead us towards improved novel therapeutic strategies other synucleinopathies.