Multifunctional upconversion–nanoparticles–trismethylpyridylporphyrin–fullerene nanocomposite: a near-infrared light-triggered theranostic platform for imaging-guided photodynamic therapy

摘要: Photodynamic therapy (PDT) is an excellent therapeutic modality for various malignant and nonmalignant cancers. This approach utilizes reactive oxygen species generated through the reaction between photosensitizer in tissues upon light irradiation to achieve effective treatment. However, limited penetration depth oxygen-deficient microenvironment hinder efficiency of PDT. In this work, we design a multifunctional near-infrared (NIR)-triggered theranostic agent based on upconversion-nanoparticles-Polyoxyethylene bis (amine)-trismethylpyridylporphyrin-fullerene nanocomposite (UCNP-PEG-FA/PC70) imaging (fluorescence/upconversion luminescence/magnetic resonance imaging)-guided photodynamic therapy. multimodal nanocompsite, UCNPs are employed as transducers convert NIR into ultraviolet-visible activate PC70 generate singlet (O-1(2)) even under low-oxygen conditions. Meanwhile, upconversion emission, magnetic fluorescence signal coming from enable UCNP-PEG-FA/PC70 act diagnostic agent, which facilitates imaging-guided Furthermore, folate-mediated active targeting would enhance accumulation hybrid tumor. vitro well vivo results suggest that smart promising light-triggered -targeted platform PDT cancer, may provide solution bottleneck problems PDT, namely, microenvironment.