Two cyclic dipeptide anticonvulsants : cyclo-glycyl-L-phenylglycine (1) and cyclo-L-alanyl-D-phenylglycine (2)

摘要: In the title compounds, C 10 H N 2 O .0.25H (1) and 11 12 (2), phenyl rings are almost perpendicular to mean planes of diketopiperazine rings, which assume flattened twist-boat conformations. The methyl group alanyl residue in (2) lies a quasiaxial position. both structures, hydrogen bonds connect molecules into infinite layers. compound (1), there two per asymmetric unit each forms an independent layer. Water bind neighboring layers only one type pairs. There is no interaction between symmetrically