Oral retinoid therapy for disorders of keratinization: single-centre retrospective 25 years' experience on 23 patients.

摘要: Summary Background  Over the last three decades, oral retinoids etretinate and acitretin have revolutionized treatment of disorders keratinization (DOK). Many patients with DOK require life-long retinoids. However, longest follow-up data on retinoid therapy is 10 years for adults up to 11 years children. Objectives  The aim our study was collect long-term retrospective including disease response, side-effects pregnancy outcome in a cohort who were among first world commence 25 years ago. Methods  Between 1979 1981, 30 commenced department. Case notes these reviewed retrospectively, interviewed where possible obtain following information: diagnosis, age when commenced, duration treatment, reason discontinuation therapy, side-effects, abnormal investigation results outcomes. Results  23 available review; these, two deceased 14 interviewed. In patients, mean commencing 33·5 years (range 4·2–61) 5·2 years 1 month 14 years). Reasons discontinuing an overall improvement skin (six 23), no benefit ± (11 23) noncompliance (one 23). Two died causes unrelated their or 12 4 years after stopping etretinate. Five female, four males) subsequently changed are currently continuing therapy. total (etretinate acitretin) males 23·7 years 20·6–25·1). female patient continued intermittent courses (due planned pregnancies) 10·1 years over 25 years. Abnormal included elevated serum triglycerides cholesterol (two isolated high (three worsening liver enzymes alcohol dependence, alkaline phosphatase (ALP) healthy children, pretreatment ALP levels increased further but returned normal adulthood while continued. One developed diffuse idiopathic skeletal hyperostosis 21 years had early spontaneous abortions 2·75 3·2 years etretinate; she children. other females children 1, 3 5 years male fathered etretinate. Conclusions  This provides Such information essential clinicians embarking