Musashi signaling in stem cells and cancer.

摘要: How a single cell gives rise to an entire organism is one of biology's greatest mysteries. Within this process, stem cells play key role by serving as seed capable both self-renewal sustain themselves well differentiation generate the full diversity mature and functional tissues. Understanding how balance between achieved crucial defining not only underpinnings normal development but also its subversion can lead cancer. Musashi, family RNA binding proteins discovered originally in Drosophila named after iconic samurai, Miyamoto has emerged signal that confers protects state across organisms. Here we explore reactivation be critical element oncogenesis. Relative long-established developmental signals such Wnt, Hedgehog, Notch, our understanding Musashi remains infancy; yet all evidence suggests will emerge equally powerful paradigm for regulating cancer may destined have great impact on biology medicine.