摘要: Pharmacology is currently transformed by the vast amounts of genome-associated information available for system-level interpretation. Here I review potential systems biology to facilitate this interpretation, thus paving way emerging field pharmacology. In particular, will show how gene regulatory and metabolic networks can serve as a framework interpreting high throughput data an interface detailed dynamical models. addition established connectivity analyses effective networks, suggest here also analyze higher order architectural properties networks.
sci-hub.se 参考文章(60)
James Smith, Marc-Thorsten Hütt, Network Dynamics as an Interface between Modeling and Experiment in Systems Biology Systems Biology in Psychiatric Research. pp. 243- 276 ,(2010) , 10.1002/9783527630271.CH12
Muhammed A Yıldırım, Kwang-Il Goh, Michael E Cusick, Albert-László Barabási, Marc Vidal, Drug—target network Nature Biotechnology. ,vol. 25, pp. 1119- 1126 ,(2007) , 10.1038/NBT1338
Ruiling Zhang, Qin Miao, Chuansheng Wang, Rongrong Zhao, Wenqiang Li, Colin N. Haile, Wei Hao, Xiang Yang Zhang, Genome-wide DNA methylation analysis in alcohol dependence. Addiction Biology. ,vol. 18, pp. 392- 403 ,(2013) , 10.1111/ADB.12037
Leland H. Hartwell, John J. Hopfield, Stanislas Leibler, Andrew W. Murray, From molecular to modular cell biology. Nature. ,vol. 402, ,(1999) , 10.1038/35011540
Christopher C. Page, Christopher C. Moser, Xiaoxi Chen, P. Leslie Dutton, Natural engineering principles of electron tunnelling in biological oxidation-reduction. Nature. ,vol. 402, pp. 47- 52 ,(1999) , 10.1038/46972
S. Bornholdt, SYSTEMS BIOLOGY: Less Is More in Modeling Large Genetic Networks Science. ,vol. 310, pp. 449- 451 ,(2005) , 10.1126/SCIENCE.1119959
Christoph Gille, Christian Bölling, Andreas Hoppe, Sascha Bulik, Sabrina Hoffmann, Katrin Hübner, Anja Karlstädt, Ramanan Ganeshan, Matthias König, Kristian Rother, Michael Weidlich, Jörn Behre, Herrmann‐Georg Holzhütter, HepatoNet1: a comprehensive metabolic reconstruction of the human hepatocyte for the analysis of liver physiology Molecular Systems Biology. ,vol. 6, pp. 411- 411 ,(2010) , 10.1038/MSB.2010.62
Alexey V. Gorshkov, Thomas Pohl, Mikhail D. Lukin, Vladan Vuletić, Thibault Peyronel, Ofer Firstenberg, Qi-Yu Liang, Sebastian Hofferberth, Quantum nonlinear optics with single photons enabled by strongly interacting atoms Nature. ,vol. 488, pp. 57- 60 ,(2012) , 10.1038/NATURE11361
Alan Mathison Turing, The Chemical Basis of Morphogenesis Philosophical Transactions of the Royal Society B. ,vol. 237, pp. 37- 72 ,(1952) , 10.1098/RSTB.1952.0012
Nikolaus Sonnenschein, Carsten Marr, Marc-Thorsten Hütt, A topological characterization of medium-dependent essential metabolic reactions. Metabolites. ,vol. 2, pp. 632- 647 ,(2012) , 10.3390/METABO2030632