作者: Faiez Zannad , Jean-Marc Boivin , Lorraine General Physician Investigators Group
DOI: 10.1097/00004872-199917070-00020
关键词:
摘要: Objective To measure the time effect profiles of a once daily administered combination tablet felodipine-metoprolol 5/50 mg (Logimax®, Astra) and amlodipine 5 (Norvasc®, Pfizer) on blood pressure heart rate using 24-h ambulatory monitoring. Design Randomized multicentre parallel-group study with single-blind placebo run-in period 4 weeks duration 6-week double-blind active treatment period. Patients methods Out 245 randomized outpatients (90 men, 155 women) uncomplicated mild-to-moderate primary hypertension mean sitting diastolic (DBP) 95-115 mmHg inclusive, 212 (102 110 amlodipine) were eligible for analysis. monitoring was performed at end (baseline) after 6 (posttreatment). Results Both induced smooth consistent reduction in DBP systolic throughout period, hence not altering diurnal rhythm. However, reduced all average pressures (24-h, day- night-time) more than (for 14.4/9.5 8.9/ 5.5 mmHg, respectively). Medians individual trough-to-peak (T/P) ratios similar (54 50%, respectively), while T/P ratios, corresponding values 74 35%, repectively; no significant difference between treatments seen. As distinguished from amlodipine, both product markedly decreased even during early morning hours. In general, well tolerated. Conclusions achieved optimal control inter-dosing interval line their pharmokinetic profiles. The vasodilatory adverse events slightly reported combination, but due to pronounced lowering potent additional product, efficacy/tolerability balance seems be equal or better that obtained monotherapy such as amlodipine.