BK Channels Mediate Pathway-Specific Modulation of Visual Signals in the In Vivo Mouse Retina

摘要: The modulatory role of large-conductance Ca(2+)-activated K(+) (BK) channels in the nervous system has been extensively studied. In retina, it shown that BK play a pivotal modulating feedback from A17 amacrine cells to rod bipolar (RBCs). Here, we used electroretinography examine functional for and cone vision retina vivo using genetically engineered mouse lacking (Bk(-/-)). Under dark-adapted light-adapted conditions, lack had no effect on photoreceptor activity, suggesting these ion do not modulate responses. At cell level, ERG signals attributed RBCs Bk(-/-) mice were different those wild-type at low scotopic stimulus intensities. However, high mesopic intensities, close RBC saturation, significant reduction reflecting activity was present retina. higher intensities activating both (CBCs), difference between found. photopic paradigms, ON- OFF-CBCs retinae indistinguishable. These findings demonstrate visual responses level intermediate conditions.