The transition from acute to chronic pain: understanding how different biological systems interact

摘要: Although pain is an adaptive sensory experience necessary to prevent further bodily harm, the transition from acute chronic not and results in development of a clinical condition. How this occurs has been focus intense study for some time. The current review on changes neuronal plasticity as well role immune cells glia tissue injury pain. Our understanding complex pathways that mediate continues increase. Work area already revealed interactions between nervous system result both peripheral central sensitization, essential components Taken together, thorough characterization cellular mechanisms generate states new therapies treatments. Basic research leading therapeutic targets promising with chloride extrusion enhancers. It hoped one day they will provide relief patients A better how develops at mechanistic level can aid clinicians treating their by showing underlying biology contributes manifestations may also help identify future analgesic drugs.