Visible auto-fluorescence in biological fluids as biomarker of pathological processes and new monitoring tool
作者： A. Kuznetsov , A. Frorip , A. Maiste , M. Ots-Rosenberg , A. Sünter
DOI: 10.1142/S1793545815410035
关键词:
摘要: Comparative optical study of biofluids (serum, urine, hemodialysate) by concentration change endogenous visible fluorescence substance (VFS) has been carried out. Biofluids were collected from chronic kidney diseases (CKD) patients (Pts) as well healthy controls (HCs). Excitation/emission spectra are similar for all samples differing only in intensity, which is higher CKD Pts. Strong similarity enables the given a united physical platform, proposed earlier, i.e., nanoparticles approach. Specific spectral redistribution (VF) intensity result dilution revealed. The VFS manifests nonlinear dependences scales "VF intensity–concentration" serum and urine perfect linearity hemodialysate (HD). latter fact can be used monitoring hemodialysis procedure.
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