Which aspects of the farming lifestyle explain the inverse association with childhood allergy

摘要: Background Farmers' children have a reduced prevalence of allergic disorders. The specific protective environmental factors responsible are not yet identified. Objective We sought to determine whether farmers' in the rural county Shropshire, England, risk atopy and, if so, identify responsible. Methods Study Asthma and Allergy Shropshire was 2-stage cross-sectional study. In stage 1 questionnaire elicit status, diet, farming exposure completed by parents 4767 children. 2 stratified subsample 879 underwent skin prick testing measurement domestic endotoxin. Results Compared with nonfarming children, had significantly less current asthma symptoms (adjusted odds ratio (OR), 0.67; 95% CI, 0.49-0.91; P = .01) seasonal rhinitis OR, 0.50; 0.33-0.77; .002) but eczema 0.91; 0.68-1.21; .53) or 0.68; 0.40-1.16; .15). contrast, unpasteurized milk consumption associated 0.59; 0.40-0.87; .008) greater reduction 0.24; 0.10-0.53; .001). effect seen all independent status. Unpasteurized 59% total IgE levels ( .02). Conclusion mediating on test positivity. status present infrequent amounts milk. Clinical implications might be modifiable influence sensitization