Valganciclovir as Add-On to Standard Therapy in Secondary Glioblastoma.
作者： Giuseppe Stragliotto , Mattia Russel Pantalone , Afsar Rahbar , Cecilia Söderberg-Nauclér , None
DOI: 10.3390/MICROORGANISMS8101471
关键词:
摘要: Patients with glioblastoma have a very poor prognosis despite aggressive therapeutic strategies. Cytomegalovirus has been detected in >90% of tumors. This virus can affect tumor progression and may represent novel therapy target. We report, here, retrospective survival analysis patients secondary who were treated the anti-viral drug valganciclovir at Karolinska University Hospital Stockholm. performed analyses eight standard dose as an add-on to second-line after their disease glioblastoma. Thirty-six admitted during same time period received similar treatment care served contemporary controls. The showed increased median overall compared controls (19.1 versus 12.7 months, p = 0.0072). result indicates potential positive effect glioblastoma, which is agreement our previous observation that improves outcomes newly diagnosed Larger randomized studies are warranted prove this hypothesis.
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