[Oxybutinin-desmopressin association in the treatment of primary nocturnal enuresis with diurnal urination disorders].

摘要: BACKGROUND Since most of the children observed in our Centre present enuresis with voiding disturbance, we carried out a study where these patients were treated DDAVP + Oxybutinin association. METHODS We have 89 and disturbances (urge incontinence, urgency, urinated > 7 times day), administering drugs combination desmopressin (20 micrograms/daily) oxybutinin (0.3-0.6 mg/kg/bid or tid) for variable period, depending on response to treatment. RESULTS The results demonstrate efficacy this association: reduction average bed wetting nights from 23.4 nights/month 6.4 wet after 1 month, 3.8 ad 2.9 respectively 3 6 months beginning. Moreover obtained recovery all daily months. Fifty percent cured 4 therapy finally 93.2% recovered at On other hand, 2 no-responders even 9 combined administration. CONCLUSIONS Based can affirm that nocturnal disturbance be therapy. Actually, urinary output thus lower bladder filling, due desmopressin, decreases onset uninhibited contractions enhances activity.